Every year an estimated three million newborn babies die during the first week of life due to problems such as sepsis tetanus or asphyxia or problems associated with trauma low birth weight or preterm birth. This guide is written for the doctors nurses senior midwives and other health care workers at the first referral level in low resource settings who are responsible for thecare of newborn babies with problems during the first week(s) of life. The guide based on the latest available evidence provides up-to-date authoritative clinical guidelines that are relevant to a facility with basic lab.